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As future amino acid-based treatments seem to depend on identifying potent ligands to promote endogenous GLP-1 secretion in humans, and as the effects of oral amino acid supplementation on GLP-1 secretion in humans have been variable [44, 47,48,49], the effect of the individual amino acids on GLP-1 secretion in humans warrants further clarification
In a mouse model of ovarian cancer, immature DC (defined as CD11c + DEC-205 + CD8 + CD80 - ) were also found in the TME, where they were recruited in a -defensin-dependent manner (92)
Trials like IRMA-2 (Parving et al, NEJM 2001) demonstrate a reduced risk of progression of CKD in patients with diabetes and moderately increased albuminuria (30-300mg/day) using RAS blockade
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